Giorgio V Scagliotti Selected Research

Pemetrexed (MTA)

1/2019	Nintedanib in combination with pemetrexed and cisplatin for chemotherapy-naive patients with advanced malignant pleural mesothelioma (LUME-Meso): a double-blind, randomised, placebo-controlled phase 3 trial.
1/2017	LUME-Meso: Design and Rationale of the Phase III Part of a Placebo-Controlled Study of Nintedanib and Pemetrexed/Cisplatin Followed by Maintenance Nintedanib in Patients With Unresectable Malignant Pleural Mesothelioma.
1/2017	Meta-analysis examining impact of age on overall survival with pemetrexed for the treatment of advanced non-squamous non-small cell lung cancer.
1/2017	Safety Analyses of Pemetrexed-cisplatin and Pemetrexed Maintenance Therapies in Patients With Advanced Non-squamous NSCLC: Retrospective Analyses From 2 Phase III Studies.
9/2015	Phase I Study of Lapatinib and Pemetrexed in the Second-Line Treatment of Advanced or Metastatic Non-Small-Cell Lung Cancer With Assessment of Circulating Cell Free Thymidylate Synthase RNA as a Potential Biomarker.
4/2014	Randomized phase II study of pemetrexed/cisplatin with or without axitinib for non-squamous non-small-cell lung cancer.
12/2013	An open-label, multicenter, randomized, phase II study of pazopanib in combination with pemetrexed in first-line treatment of patients with advanced-stage non-small-cell lung cancer.
5/2012	Comparison of pemetrexed plus cisplatin with other first-line doublets in advanced non-small cell lung cancer (NSCLC): a combined analysis of three phase 3 trials.
6/2010	A randomized phase II study of bortezomib and pemetrexed, in combination or alone, in patients with previously treated advanced non-small-cell lung cancer.
3/2010	Thymidylate synthase but not excision repair cross-complementation group 1 tumor expression predicts outcome in patients with malignant pleural mesothelioma treated with pemetrexed-based chemotherapy.

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Giorgio V Scagliotti Research Topics

Disease

60	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022 - 01/2003
52	Neoplasms (Cancer) 04/2022 - 05/2003
26	Lung Neoplasms (Lung Cancer) 01/2022 - 07/2003
15	Adenocarcinoma 01/2021 - 05/2002
13	Malignant Mesothelioma 01/2022 - 04/2003
12	Prostatic Neoplasms (Prostate Cancer) 02/2022 - 03/2016
12	Carcinoma (Carcinomatosis) 04/2018 - 05/2002
11	Neoplasm Metastasis (Metastasis) 04/2022 - 12/2004
9	Disease Progression 05/2021 - 07/2003
9	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2021 - 05/2002
5	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 05/2021 - 06/2008
5	Mesothelioma 01/2017 - 02/2006
5	Large Cell Carcinoma 05/2012 - 05/2002
4	Neutropenia 01/2019 - 01/2012
3	Adenocarcinoma of Lung 10/2021 - 06/2006
3	Fatigue 04/2018 - 06/2012
3	Bronchiolo-Alveolar Adenocarcinoma (Adenocarcinoma, Bronchiolo Alveolar) 11/2006 - 10/2005
2	Pain (Aches) 04/2022 - 03/2016
2	Pleurisy (Pleuritis) 01/2021 - 01/2019
2	Breast Neoplasms (Breast Cancer) 07/2020 - 08/2003
2	Hypoxia (Hypoxemia) 05/2018 - 08/2014
2	Adrenocortical Carcinoma 06/2017 - 08/2014
2	Urinary Bladder Neoplasms (Bladder Cancer) 03/2017 - 01/2017
2	Lymphatic Metastasis 01/2015 - 09/2010
2	Osteosarcoma (Osteogenic Sarcoma) 11/2013 - 09/2012
2	Exanthema (Rash) 06/2012 - 10/2011
1	Femoral Fractures (Femoral Fracture) 04/2022
1	Osteonecrosis (Kienbock's Disease) 04/2022
1	Hypocalcemia 04/2022

Drug/Important Bio-Agent (IBA)

23	Cisplatin (Platino)FDA LinkGeneric 01/2019 - 07/2003
21	Pemetrexed (MTA)FDA Link 01/2019 - 04/2003
11	Proteins (Proteins, Gene)FDA Link 03/2016 - 05/2002
11	Thymidylate SynthaseIBA 09/2015 - 02/2006
10	PlatinumIBA 05/2021 - 07/2003
10	Gemcitabine FDA Link 01/2013 - 07/2003
8	Biomarkers (Surrogate Marker)IBA 01/2022 - 07/2008
8	enzalutamideIBA 12/2021 - 03/2016
8	Carboplatin (JM8)FDA LinkGeneric 08/2014 - 01/2005
7	ErbB Receptors (EGF Receptor)IBA 05/2021 - 06/2004
6	abirateroneIBA 12/2021 - 03/2016
6	Tyrosine Kinase InhibitorsIBA 05/2021 - 11/2006
6	Hormones (Hormone)IBA 07/2020 - 11/2012
6	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2019 - 11/2006
6	Docetaxel (Taxotere)FDA Link 01/2018 - 01/2003
6	Paclitaxel (Taxol)FDA LinkGeneric 08/2014 - 12/2004
5	Pharmaceutical PreparationsIBA 01/2022 - 04/2012
5	Biological ProductsIBA 01/2022 - 03/2009
5	Messenger RNA (mRNA)IBA 03/2013 - 10/2006
4	LigandsIBA 04/2022 - 09/2007
4	AndrogensIBA 01/2021 - 08/2017
4	Abiraterone AcetateIBA 01/2021 - 08/2017
4	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2019 - 08/2012
4	DNA (Deoxyribonucleic Acid)IBA 03/2016 - 11/2009
3	AsbestosIBA 01/2022 - 07/2008
3	ARQ 197IBA 01/2019 - 09/2012
3	MucinsIBA 01/2019 - 09/2007
3	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2018 - 01/2005
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2017 - 05/2006
3	Vinorelbine (Navelbine)FDA LinkGeneric 01/2013 - 12/2004
3	Gefitinib (Iressa)FDA Link 10/2011 - 11/2006
3	Folic Acid AntagonistsIBA 03/2009 - 02/2006
3	Epidermal Growth Factor (EGF)IBA 09/2007 - 08/2003
2	Denosumab FDA Link 04/2022 - 03/2016
2	Diphosphonates (Bisphosphonates)IBA 04/2022 - 12/2005
2	Zoledronic Acid (Zometa)FDA Link 04/2022 - 03/2016
2	Radium-223IBA 02/2022 - 03/2016
2	Circulating Tumor DNAIBA 10/2021 - 01/2018
2	1-methyl-1-piperidinomethane sulfonateIBA 01/2021 - 01/2018
2	Phosphotransferases (Kinase)IBA 01/2019 - 01/2017
2	nintedanibIBA 01/2019 - 01/2017
2	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 01/2019 - 08/2012
2	Leucovorin (Folinic Acid)FDA Link 05/2018 - 01/2018
2	Fluorouracil (Carac)FDA LinkGeneric 01/2018 - 02/2008
2	Bevacizumab (Avastin)FDA Link 01/2017 - 11/2009
2	AntigensIBA 01/2017 - 03/2016
2	Dasatinib (BMS 354825)FDA Link 03/2016 - 11/2009
2	ParaffinIBA 03/2015 - 10/2006
2	Formaldehyde (Formol)FDA Link 03/2015 - 10/2006
2	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 01/2015 - 03/2013
2	MicroRNAs (MicroRNA)IBA 01/2015 - 08/2014
2	motesanib diphosphateIBA 08/2014 - 08/2012
2	Guanidine (Guanidine Nitrate)FDA Link 11/2013 - 09/2012
2	NucleotidesIBA 03/2013 - 06/2004
2	Sunitinib (Sutent)FDA Link 06/2012 - 02/2008
2	src-Family KinasesIBA 04/2012 - 11/2009
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 04/2012 - 11/2009
2	Cytotoxins (Cytolysins)IBA 05/2009 - 01/2003
2	Etoposide (VP 16)FDA LinkGeneric 06/2008 - 12/2004
2	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 01/2007 - 04/2003
2	AntimetabolitesIBA 10/2006 - 02/2006
1	Opioid Analgesics (Opioids)IBA 04/2022

Therapy/Procedure

32	Therapeutics 01/2022 - 04/2003
31	Drug Therapy (Chemotherapy) 01/2022 - 07/2003
12	Castration 02/2022 - 03/2016
8	Immunotherapy 01/2022 - 01/2016
4	Radiotherapy 01/2017 - 10/2003
3	Precision Medicine 10/2021 - 01/2017
3	Neoadjuvant Therapy 12/2018 - 08/2003
3	Adjuvant Chemotherapy 07/2005 - 10/2003
2	Chemoradiotherapy 12/2004 - 01/2003